You are currently browsing the daily archive for December 14, 2021.

Two videos of interest follow concerning coronavirus vaccines, including boosters.

On Monday, December 13, 2021, Health Secretary Sajid Javid said in Parliament that NHS work would be largely paused to focus on the booster programme, with which the British Army will help administer.

An oncologist, Prof. Angus Dalgleish from St George’s Hospital, London, told GB News that the booster programme was ‘a waste of time’, because the new Omicron variant is so infectious. He is concerned that many other ailments, cancer, in particular, will go untreated. He says that a relatively mild cancer which goes undetected can become Stage 4 cancer, bringing about more fatalities from non-COVID illnesses. As for the vaccines, he says that the focus should be on T-cells rather than antibodies, which can disappear over time.

This is around six minutes in length and well worth watching:

A longer video about the vaccines is on Parliamentlive.tv. I recommend the first 40 minutes with Dame Kate Bingham, Former Chair, UK Vaccine Taskforce. (Scroll through the first 10 minutes or so, as the start was delayed.) On December 14, 2021, Dame Kate told the Science and Technology Select Committee how the vaccine programme, which was her big success last year, has begun to falter.

She has been out of the taskforce for a year now. She told the Select Committee that she left a detailed plan behind of how to proceed: staying ahead of the curve both with variants and vaccine supply. She surmises that her plan has not been followed, for whatever reason, because the vaccine rollout has become inefficient.

The most eye-opening part was her discussion of the Valneva lab in Livingston, Scotland. Dame Kate said that the Government recently withdrew funding from the facility because they wanted booster shots only; Valneva produces whole-virus vaccines, which are seen to be more adaptable in the long run.

Valneva was supposed to be 2021’s big success story. Prime Minister Boris Johnson visited the facility earlier this year.

Although Valneva is a French company, in February, they were willing to ship their vaccines to the UK first, because the EU had not yet signed a letter of intent:

Guido Fawkes reported that the vaccine would be ready in 2022 (emphasis in the original):

This morning it was revealed that the UK has exercised its option to purchase a further 40 million doses of a promising new vaccine from Valneva SE, a French vaccine developer with its product still in stage 1/2 trials. While the vaccine would not be available until next year it could prove vital in defending against new strains as the UK deploys what will likely be an annual vaccination effort similar to the massive flu jabs programme. The UK had already ordered 60 million doses, bringing the total to 100 million…

Valneva SE CFO David Lawrence told the Today Programme that whilst the UK has been in discussions and had signed deals since the summer of 2020, the EU is yet to sign even a letter of intent with the firm, which is headquartered in Paris.

In April, The Scotsman reported that Valneva was searching for Phase 3 trial volunteers for their promising vaccine, being developed ahead of schedule for delivery at the end of 2021 (emphases mine; sorry about the font size, which I was unable to change):

The UK has ordered 100 million doses of the Valneva vaccine, which are set to be delivered at the end of 2021 and beginning of 2022.

With all adults due to have been vaccinated by the end of the summer, Valneva hopes its vaccine will be used as a booster jag or as a modified vaccine which is more effective against new variants of Covid-19.

The phase 3 trial will run in 24 sites across the UK, with two in Scotland. It is open to healthy adults who have not already had a vaccine.

Around 3,000 people over 30 will be given either two doses of the Valneva vaccine or two doses of the AstraZeneca jag.

Following JCVI guidance not to offer AstraZeneca to under 30s, around 1,000 younger participants in the study will be given only the Valneva option.

Volunteers will be given two doses, 28 days apart, starting at the beginning of May.

Thomas Lingelbach, Valneva chief executive, said: “This Phase 3 initiation marks a significant milestone in the development of the only inactivated vaccine candidate against Covid-19 in clinical trials in Europe.

“As Covid-19 continues to impact people’s daily lives, we remain fully focused on developing another safe and efficacious vaccine solution.

“We believe that VLA2001 has an important role to play including boosters or potential modifications to the vaccine to address variants.”

Valneva’s candidate is an inactivated whole virus vaccine, which contains virus that has been destroyed so cannot infect cells, but can still trigger an immune response.

The technology is used in flu, polio and rabies vaccines, and it’s a more traditional approach than the Pfizer (mRNA) and AstraZeneca (adenoviral) vaccines.

Because the vaccine doesn’t contain any live virus, it may be especially suitable for vulnerable people, such as the elderly or those with weaker immune systems.

On November 31, Daily Business reported that the UK Government might return to the negotiating table with Valneva, which they had accused of breach of contract:

UK Government ministers may be about to return to the negotiating table with French vaccine developer Valneva two months after cancelling a contract to supply Covid vaccines from its plant in Livingston.

A source close to the situation says it is hoped the UK Government will “seek an amicable resolution” and at least partially reinstate the £1.2bn order to help combat the new Omicron variant.

Westminster terminated the deal in September, claiming breach of contract, a move that drew criticism from business leaders, senior academics and politicians.

The government had placed an order for 100 million doses of its VLA2001 vaccine after increasing its request by 40 million last February. Then, without warning, it pulled the plug.

It placed a question mark over the future of the firm’s new West Lothian factory, a globally-qualified manufacturing site for viral vaccines including VLA2001.

The company is currently supplying, or is in discussion, with other countries about potential deals for the vaccine.

For once, I agree with Scottish National Party (SNP) MPs; they rightly deplore the Government’s withdrawal of the Valneva order.

Dame Kate Bingham pointed out that, because Valneva’s vaccine is a whole virus one rather than one with just the protein spikes, e.g. Moderna’s, it can be modified quickly to attack new variants. Moderna’s and Pfizer’s, on the other hand, require months of work.

Dame Kate called Valneva ‘nimble’. She added that, even if the UK were not interested in the vaccine, other countries around the world would want it, which can only be a positive for Britain.

One wonders how many other stories there are like this.

© Churchmouse and Churchmouse Campanologist, 2009-2022. Unauthorized use and/or duplication of this material without express and written permission from this blog’s author and/or owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Churchmouse and Churchmouse Campanologist with appropriate and specific direction to the original content.
WHAT DOES THIS MEAN? If you wish to borrow, 1) please use the link from the post, 2) give credit to Churchmouse and Churchmouse Campanologist, 3) copy only selected paragraphs from the post — not all of it.
PLAGIARISERS will be named and shamed.
First case: June 2-3, 2011 — resolved

Creative Commons License
Churchmouse Campanologist by Churchmouse is licensed under a Creative Commons Attribution 2.0 UK: England & Wales License.
Permissions beyond the scope of this license may be available at https://churchmousec.wordpress.com/.

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 1,541 other followers

Archive

Calendar of posts

December 2021
S M T W T F S
 1234
567891011
12131415161718
19202122232425
262728293031  

http://martinscriblerus.com/

Bloglisting.net - The internets fastest growing blog directory
Powered by WebRing.
This site is a member of WebRing.
To browse visit Here.

Blog Stats

  • 1,688,311 hits